Searching for cyanide
by Justine de Valicourt Overview Cyanide is a strongly toxic compound that is frequent in nature, including in some plants generally considered safe. We investigated its pathway to have a better understanding of its toxicity. A lot of food contains small concentrations of cyanide in the form of glycosides. When the plant is hurt or chewed a chemical reaction occurs in the harmed cell and the cyanide is released as a natural defense. This poison blocks the cell’s uptake of oxygen, bringing on a cellular condition called histotoxic anoxia, lit. ‘cell toxic lack of oxygen’. The cell is no longer able to produce energy for its normal functions and quickly dies. The human body can detoxify a small amount of cyanide in the liver through a pathway involving a molecule called thiosulfate. Poisoning occurs when there is not enough thiosulfate to neutralise all the cyanide. At low toxic concentrations the … Read more